Updated March 28, 2020
Reprinted with permission from the authors.
Written by Roberto Sussman* and Carmen Escrig**
*Institute for Nuclear Sciences, National University of México UNAM. Physics PhD. Director of Pro-Vapeo México AC
**Universidad Autónoma de Madrid, Spain. Biology PhD specialized in Virology. Coordinator of the Medical Platform for Tobacco Harm Reduction in Spain.
The misinformation pandemic
Unfortunately, the spread of the SARS-CoV-2 pandemic follows the years long ongoing pandemic of serious misinformation on vaping. One of the main spearheads of this misinformation is undoubtedly Professor Stanton Glantz from the University of California at San Francisco. In his professional blog1 Professor Glantz squarely puts vaping and smoking on equal footing as serious risk factors for progression to COVID-19. Specifically, Glantz justifies this assessment by stating that:
The recent excellent summary of the evidence on the pulmonary effects of e-cigarettes reported multiple ways that e-cigarettes impair lungs’ ability to fight off infections:
a statement followed by listing a litany of adverse effects of vaping on respiratory infections, all taken from studies examined in the review by Gotts et al2 (the “excellent summary”). While recognizing that Vapers’ risk of viral infections has not been studied much, the popular journal Scientific American3 has cited Glantz and has also recycled some of the results reported by Gotts et al.
The review by Gotts et al, which Glantz and Scientific American take as source, is extremely superficial, biased and selective, it cited uncritically only studies reporting adverse effects, all of which are either acute effects without clinical relevance or cross sectional studies based on small samples of vapers in which the huge confounding effect of previous smoking history was not properly handled (see a critique of such studies in a much more balanced and extensive review of respiratory effects4 of vaping). Moreover, Gotts et al (and Glantz quoting them) interpret the results in a very selective manner. A representative example of their modus operandi is furnished by their assessment of the results obtained by one of the revised studies by Saudt et al5. From Glantz’s exact quote of Gotts et al we have
Healthy non-smokers were exposed to e-cigarette aerosol, and bronchoalveolar lavage was obtained to study alveolar macrophages. The expression of more than 60 genes was altered in e-cigarette users’ alveolar macrophages two hours after just 20 puffs, including genes involved in inflammation.
Curiously, Gotts et al and Glantz omit mentioning that the effects examined in5 were acute and that the same study reports that “No significant changes in clinical parameters were observed”. Gotts et al and Glantz quoting them also omit mentioning evidence pointing in the opposite direction: as reported by several studies reviewed in3 the usage of e-cigarettes actually reduces the presence of pathogens and respiratory infections. A significant decrease of respiratory infections in e-cigarette users has also been reported in a large scope randomized controlled trial researching smoking cessation6, a result based on a 12 months long clinical observation on a large sample of subjects. This result (and similar results in other randomized trials reviewed in7) are real life observational results that are more relevant to assess the immune response of vapers in the context of COVID-19 than the adverse acute effects in idealized lab studies reported uncritically by Gotts et al in2 and recycled by Glantz and Scientific American.
Professor Glantz is perhaps the most vocal spearhead, but he is far from being the only academic in the vast USA sourced anti-vaping activism, which is now presenting the relation of vaping and the SARS-CoV-2 pandemic through the grossly biased assessments from reviews like that of Gotts et al, conflating carelessly the risks of vaping and smoking and ignoring all contrary or critical evidence. It is very unfortunate that mainstream academia, politicians and the media in the USA is predominantly fed by this constant flow of misinformation, as can be seen in statements by the Major of New York City, Bill de Blasio8, and by various media outlets9.
COVID-19 and smokers
A good reference reviewing the available evidence on the relation between smoking, vaping and COVID-19 is the article written by Farsalinos, Barbouni and Nyaura10 (see also the professional blog entry of Farsalinos11). The authors conclude after reviewing the data from five studies on patients infected by SARS-CoV-2 that the relation between smoking cigarettes and the severity of COVID-19 in infected Chinese patients is uncertain and even protective (bearing in mind that 52.1% of Chinese men smoke whereas only 2.7% of women do). In his blog entry Farsalinos examines in more detail the data from the study with the largest sample12: 1096 patients, of whom only 12.5% were current smokers (1.9% ex-smokers), which (as in the other studies) is a much lesser proportion than that found among the population bearing in mind that 58.1% of the sample were men and practically 100% older than 15 years (to be representative of the population we would expect the proportion of smokers in the sample to be 29%). Of the 1096 patients:
- 926 were reported without severe affectation (11.8% smokers)
- 173 were reported with severe affectation (11.8% smokers)
- 67 were reported in critical situation with intensive care, mechanical ventilation or dead (25.8% smokers)
These numbers indicate a higher proportion of smokers among those with severe outcomes, but still lower than in the general Chinese population given the high smoking prevalence among Chinese men. Evidently, smoking contributes to identified vulnerability conditions, such as cardiovascular ailments, diabetes or chronic lung disease. More information on the relation between smoking and COVID-19 is likely to emerge gradually as more data becomes available (see for example13).
The effect of COVID-19 on vapers
Contrary to statements by misinformation sources, there is simply no compelling evidence suggesting that vaping has the capacity to affect negatively the immune body response in order to produce the development and progression of the diseases caused by SARS-CoV-2 on e-cigarette users.
To better understand the possibility of a progression of infection leading to COVID-19 in vapers it is necessary to bear in mind that the overwhelming majority are smokers or ex-smokers, some of them dragging long histories of previous smoking. This smoking history is very likely an important factor that could easily render as vulnerable a vaper who (say) smoked 20 or 30 years, even if he/she has been (typically) 2-3 years vaping without smoking. Such vaper would be more susceptible to the complicated etiology of COVID-19. However, this is not an intrinsic effect of vaping, but of smoking, and thus it does not justify casting vaping as a risk factor on equal footing as smoking (as inferred from misleading statements by Glantz that have been recycled by the media).
In fact, bearing in mind that smokers improve their biomarkers and their respiratory and cardiovascular conditions when they switch completely to vaping, it is highly plausible (as Farsalinos argues11) that they would have a better prognosis under possible progression of COVID-19 if they no longer smoke, even if they have smoked before. This effect would be even more pronounced if it turns out that smoking is a determinant factor in the evolution to severe complications from COVID-19.
It is also important to stress that there cannot be contagion of SARS-CoV-2 virus through e-liquids containing the virus. Pathogens have been detected on e-liquids, however contagion of SARS-CoV-2 virus or any other pathogen is impossible from this route, as no pathogen can survive at temperatures of 180-220 degrees Celsius involved in the aerosol generation from the e-liquid (they stop functioning as the macromolecules making them up fragment).
Propylene glycol as a disinfectant
There has been mention in social networks that vaping might be protective in comparison with smoking on infection risks from COVID-1914, pointing out to experiments conducted in the 1940’s in which propylene glycol (PG) vapor was used as environmental disinfectant that removes pathogens in hospitals, military barracks and other places. The experimental procedure was as follows15,16: pathogens (bacteria) were delivered in aqueous droplets from aerosolized cultures into the test chamber (the control being a chamber with pathogens without the PG aerosol). PG aerosol or PG vapor is then continuously supplied into the test chamber with a ventilator evenly dispersing it. Tests for various ranges of ambient temperatures and relative humidity levels were conducted with various procedures to collect the bacteria. As the PG droplets in the aerosol rapidly evaporate they release PG vapor at concentrations between 0.05 and 0.66 ppm or 200 to 3000 μg/m3 (micrograms per cubic meter). The cleansing effect was most efficient at lower temperatures (in the range 15-37 degrees C) and under intermediate relative humidity levels (between 27% and 91%, peaking at around 42%), though the cleansing effect was still possible (though slower) at low relative humidity (10%) with sufficiently high PG vapor concentration.
The physical property explaining this effect17 is the hygroscopic nature of PG vapor (not the aerosol droplets). As the PG droplets evaporate below air saturation they release PG vapor molecules dispersing at high velocities and (because hygroscopicity) these molecules condense (are rapidly accreted) into the aqueous droplets containing the pathogens. The latter are eliminated by numerous fast collisions with the accreted PG molecules once the latter accumulate to form 70-80% of the droplets mass. This effect is no longer effective in both extremes of humidity: at 0% relative humidity the droplets evaporate very fast and at close to 100% relative humidity they condense, leading to a steady state which limits the available PG vapor (see17 for details).
It is difficult to relate these highly controlled and idealized experiments to the erratic and highly variable conditions in vaping. For starters, pure PG (as aerosol or as vapor) in these experiments was supplied continuously and spread evenly, whereas in vaping the aerosol is a mixture of PG and other compounds (glycerol, VG, nicotine, with residual concentrations of mostly aldehydes), it is supplied into the surrounding air (when inhaled or exhaled) intermittently during puffs and spreads unevenly. Second, PG concentrations in vaping are very variable, rapidly changing with time and position. While PG concentrations in the experiments might match those of inhaled vapor, this disinfectant effect is unlikely to occur inside the respiratory tracts in which relative humidity is close to 100%. The exhaled environmental vaping aerosol might approach better the experimental conditions: PG/VG droplets evaporates rapidly, thus releasing PG vapor molecules, while relative humidity levels of 40-70% are not unrealistic, but PG vapor concentrations might be too low (chamber studies measure about 200 μg/m3 (micrograms per cubic meter)18,19 the lower limit concentrations in the experiments in15,16).
Moreover, given the observed reduction of respiratory infections in users of e-cigarettes, it is possible to speculate that at least in some occasions environmental conditions allowing for this effect could have occurred when vaping. The air cleansing experiments conducted in the 1940’s only involved bacteria and the influenza virus, there is no way without experimental evidence to infer if this could happen with SARSCoV-2 and in the conditions of environmental e-cigarette aerosol. Many viruses (and there is ample variation on this) cannot survive long time outside the protective envelope of a humid medium (the saliva droplets) or outside their host cell in the body tissues. However, it is not known if this is the case also with SARS-CoV-2.
Exhaled vapor as a possible path to spread SARS-CoV-2
A worrying theoretically possible path of infection of the SARS-CoV-2 virus is by breathing environmental aerosol (i.e. “vapor”) exhaled by vapers. Can this exhaled vapor spread SARS-CoV-2? As stated by Rosanna O’Connor, director of the Tobacco Alcohol and Drugs of Public Health England20, currently there is no evidence of contagion through vapor exhaled by users of e-cigarettes. Professor Neil Benowitz of the University of California at San Francisco21 declared that:
It is my understanding that exhaled e-cigarette vapor consists of very small particles of water, propylene glycol and glycerin and flavor chemicals, not droplets of saliva. The vaping aerosol evaporates very quickly, while particles that are emitted when coughing or sneezing are large particles that persist in the air for a relatively long period of time. Thus, I would not think that vapers present any risk of spreading COVID-19, unless they are coughing when they exhale the vapor.
As a contrast to these declarations, the Scottish microbiologist Tom McLean, chief scientific advisor of the Nanotera Group, claims22 that exhaled vapor can spread the virus, even comparing exposure to exhaled vapor as “being spit in your face”. As we show below, McLean’s statements are completely mistaken, while Rosanna O’Connor and Professor Benowitz are right (though Benowitz’s description of contagion through aerosol droplets is oversimplified).
Airborne contagion of SARS-CoV-2 might occur through exposure associated to two types of airborne bioaerosols23: (1) large saliva droplets transmission from the exhaled breath of an infected person laying sufficiently close24 and (2) larger distance transmission of buoyant smaller droplets or droplets nuclei (5-10 micron solid residues containing the pathogens that result when the droplets evaporate) when the infected person sneezes or coughs25,26. The exhaled vapor from an infected e-cigarette user is a nonbiological aerosol potentially carrying pathogens, as it is bound to carry into the environment buoyant droplets produced by atomization of secretions in the respiratory system of the vaper24. The key issue is how its flow dynamics and pathogen content compares with that of the above described bioaerosols.
The rate of transmission of the virus strongly depends on the air flow dynamics of the different bioaerosols. Normal sedentary breath is a nearly laminar flow in the upper respiratory tracts23, giving rise to a low velocity turbulent flow when exhaled by the nose or mouth27. It spreads very few saliva droplets (roughly 1 droplet per cubic centimeter) whose size peaks at 1 micron but grow from hygroscopic coagulation, with droplets smaller than 5 microns rapidly evaporating. The droplets are transported short distances within the personal breathing zone24,27. As a contrast, sneezing is a very rapid multiphase explosive turbulent flow whose dynamics is quite elaborate25,26: it can spread up to millions of droplets typically falling to the ground at 2 meters but smaller droplets or droplets nuclei remaining buoyant for long times and possibly travelling by diffusion and up to 6-8 meters away (even upwards by buoyant convection). Coughing is also an explosive turbulent flow that can spread thousands of droplets.
The exhaled vapor is a diluted aerosol made almost exclusively of very light and rapidly moving “particles” (propylene glycol and glycerol PG/VG droplets) suspended in a gaseous medium of nearly the same chemical composition. Since most inhaled aerosol is absorbed and exhalation favors hyperfine droplets, their mean diameters are in the 100-300 nm range28,29 (one nanometer nm is 1 billionth of a meter) and they evaporate very rapidly (20 seconds per puff). The gas is supersaturated and the whole aerosol (gas and droplets) disperses completely in less than 2-3 minutes with some droplets impacting walls or falling to the ground. Chamber experiments reveal that the exhaled cloud does not transport the droplets for large distances: at 1.5 meters from the exhalation source they are barely detectable, with their particle number density almost indistinguishable from background values for all particle sizes (submicron, PM2.5 and PM10). For low powered devices this distance is likely to be less than 1 meter.
The flow associated with exhaled vapor (or smoke) is comparable to that of gentle air blowing or mouth breathing, characterized by slightly larger velocities than breathing through the nose, but much slower than coughing or sneezing24,27,30. An infected vaper will exhale as much saliva droplets as these low velocity expiration mechanisms, but their numbers are far fewer than the rapidly evaporating PG/VG droplets in the e-cigarette aerosol. As a consequence, the saliva droplets have a negligible effect on the flow dynamics even if they experience hygroscopic growth and smaller ones evaporate with their nuclei staying buoyant for much longer times. Since the cloud of PG/VG droplets of exhaled vapor are barely detectable at 1.5 meters (less for low powered devices), it is extremely unlikely that the few pathogen containing saliva droplets dragged by the exhaled flow of an infected vaper would be transported as far as these distances even if they remain buoyant. As a contrast, sneezing and coughing are able to transport large numbers of airborne pathogens for large distances.
However, leaving aside the difference between the dynamics of the involved aerosols, an infected vaper will spread into the environment a small number of virus (a few droplets per exhalation24) and only when he/she vapes (typically 200 times per day), whereas normal breathing by any person (whether a vaper or not) implies a flow of a similar amount of virus but delivered constantly. Coughing and sneezing are also intermittent virus flows, but they spread a large number of virus only in each expiration event. In fact, breath is a far more serious contagion factor than these explosive intermittent events: two hours of normal breathing spreads more droplets than coughing 100 times30. Paradoxically, an infected vaper will spread much more virus from his/her regular breathing than from his/her vaping.
Evidently, Rosanna O’Connor and Professor Benowitz are right: exhaled vapor as a risk of SARS-CoV-2 contagion does not require more strict protective measures than those contemplated for non-vapers. The associated flow dynamics suggests that keeping the same 1.5 to 2 meters “social separation” distance recommended for non-vapers should prevent any contagion from an infected vaper. Aerosol dynamics fully corroborates that microbiologist Tom Mclean is mistaken: contagion risk from exhaled vapor is not even remotely comparable to the contagion risk from sneezing or coughing.
Contagion of COVID-19 on surfaces
One of the mechanisms of contagion of viruses is physical contact with surfaces where they lie and then to touch the mouth, nose or eyes. It is known that viruses can survive on surfaces and that typically they lie inside thin liquid films that form when the saliva droplets impact the surfaces when transported by sneezing, coughing or sneezing23. This type contagion is thus theoretically possible from saliva droplets containing SARS-CoV-2 dragged by exhaled vapor and impacting the surface, but the risk should be comparable to that from droplets impacting a sufficiently close surface from normal breath.
How long can the virus they survive? It depends on the virus: it was reported that SARS-CoV-2 remains stable, viable and functional for several hours and (in some materials) up to 3 days31, but this comes from extremely idealized laboratory experiments that bear no relation with the realistic deposition of a virus on a surface: the researchers inoculate the virus in a host liquid protective solution on the surface and afterwards verify its viability. In the case of that SARS-CoV-2 it is not known how much time the virus can survive on surfaces under realistic conditions and if they can survive without their protective envelope.
RECOMMENDATIONS TO VAPERS
On the basis of the information provided, we recommend
- If you vape do not revert to smoking (if you are a dual user try to become an exclusive vaper)
- If you enjoy vaping and do not smoke, to quit vaping must be a personal choice not an obligation
- Be discreet and do not call unwanted attention (bear in mind that these are difficult times and that a lot of non-vapers have been exposed to a lot of misinformation)
- Avoid big clouds in public at all costs (even outdoors)
- Use low powered devices whenever possible and when others are around. The risk of spreading the virus with discrete vaping in low powered devices is roughly equivalent to the risk of spreading it through normal sedentary breathing.
- Avoid vaping in enclosed public spaces and try to keep at least 2 meters distance from others when vaping outdoors
1 S.A. Glantz, Reduce your risk of serious lung disease caused by corona virus by quitting smoking and vaping. https://tobacco.ucsf.edu/reduce-your-risk-serious-lung-disease-caused-corona-virus-quitting-smoking-and-vaping
2 J.E. Gotts et al. What are the respiratory effects of e-cigarettes? BMJ 2019;366:l5275. doi: https://doi.org/10.1136/bmj.l5275
3 Tanya Lewis. Smoking or Vaping May Increase the Risk of Severe Coronavirus Infection. Scientific American. 17 March. https://www.scientificamerican.com/article/smoking-or-vaping-may-increase-the-risk-of-a-severe-coronavirus-infection1/
4 Polosa R, O’Leary R, Tashkin D, Emma R & Caruso M (2019) The effect of e-cigarette aerosol emissions on respiratory health: a narrative review, Expert Review of Respiratory Medicine. https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1649146
5 Staudt MR, Salit J, Kaner RJ, Hollmann C, Crystal RG Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes. Respir Res2018;19:78. doi:10.1186/s12931-018-0778-z pmid:29754582
6 Peter Hajek, Ph.D., Anna Phillips-Waller, B.Sc., Dunja Przulj, et al. A randomized trial of e-cigarettes versus Nicotine Replacement Therapy. N Engl J Med 2019; 380:629-637 DOI: 10.1056/NEJMoa1808779 https://bit.ly/2RWdcd0
7 Hartmann-Boyce J, McRobbie H, Bullen C, Begh R, Stead L, Hajek P. Electronic cigarettes for smoking cessation. Cochrane Database of Systematic Reviews 2016 Issue 9. Art. No.: CD010216. DOI: 10.1002/14651858.CD010216. http://onlinelibrary.wiley.com/cochranelibrary/search/
10 K. Farsalinos, A. Barbolini, R. Nyaura. Somoking,vaping and hospitalization for COVID-19. Queios ID: Z69OBA.2. https://doi.org/10.32388/Z69O8A.2
11 K Farsalinos. Smoking, vaping and the coronavirus (COVID-19) epidemic: rumors vs. evidence http://www.ecigarette-research.org/research/index.php/whats-new/2020/278-corona
12 Wei-jie Guan et al. Clinical characteristics of Coronavirus disease in China. N Engl J Med 2020; https://www.nejm.org/doi/full/10.1056/NEJMoa2002032
13 Vardavas CI, Nikitara K, COVID-19 and smoking: A systematic review of the evidence Tob. Induc. Dis. 2020;18(March):20 [link] DOI: https://doi.org/10.18332/tid/119324
15 Robertson O.H., Bigg E., Puck T.T., Miller B.F., Technical Assistance of Elizabeth A. Appell. The bactericidal action of propylene glycol vapor on microorganisms suspended in air: I. J Exp Med. 1942 Jun 1;75(6):593-610. https://www.ncbi.nlm.nih.gov/pubmed/19871209
16 Puck T.T., Robertson O.H., Lemon H.M., The bactericidal action of propylene glycol vapor on microorganisms suspended in air: II, the influence of various factors on the activity of the vapor. J Exp Med. 1943 Nov 1;78(5):387-406. https://www.ncbi.nlm.nih.gov/pubmed/19871337
17 T.T. Puck, The mechanism of aerial disinfection by glycols and other chemical agents. I Demonstration that the germicidal action occurs through the agency of the vapor phase. J Exp Med. 1947 May 31; 85(6): 729–739. doi: 10.1084/jem.85.6.729
18 Czogala, J., Goniewicz, M., Fidelus, B., Zielinska-Danch, W., Travers, M. and Sobczak, A. (2013) “Secondhand exposure to vapors from electronic cigarettes”. Nicotine Tob Res (11 December 2011 (Epub ahead of print). DOI: 10.1093/ntr/ntt203
19 J Liu, Q Liang, M J. Oldham, A A. Rostami, K A. Wagner, G Gillman, P Patel, R Savioz, M Sarkar. “Determination of Selected Chemical Levels in Room Air and on Surfaces after the Use of Cartridge- and Tank-Based E-Vapor Products or Conventional Cigarettes”. Int. J. Environ. Res. Public Health 2017, 14, 969; doi:10.3390/ijerph14090969
20 Coronavirus and vaping: Can e-cigarette clouds pass on Covid-19? https://www.standard.co.uk/news/world/vaping-coronavirus-ecigarette-cloud-expert-advice-a4386996.html
21 Coronavirus will NOT spread in vape clouds unless the e-cigarette user coughs when they exhale, scientists claim. Daily Mail. March 23rd 2020. https://www.dailymail.co.uk/news/article-8143385/Coronavirus-NOT-spread-vape-clouds-unless-e-cigarette-user-coughs.html
22 ‘Someone spitting in your face’: Coronavirus: Scottish expert warns of vaping dangers. Glasgow Evening Times. 16th March 2020. https://www.glasgowtimes.co.uk/news/18309649.someone-spitting-face-coronavirus-scottish-expert-warns-vaping-dangers/
23 J.M. Macher, J. Douwes, B. Prezant and T. Reponen, Bioaerosols. Chapter 12. Aerosols Handbook, Measurement, Dosimetry and Health Effects. Second Edition. Edited by L.S. Ruzer and N.H. Harley. CRC Press. Taylos & Francis Group, Boca Raton, London, New York 2013
24 L. Morawska, G.R. Johnson, Z.D. Ristovski et al. Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities. Aerosol Science 40 (2009) 256-269. https://doi.org/10.1016/j.jaerosci.2008.11.002
25 L. Bourouiba, E. Dehandschoewercker, J. W. M. Bush. Violent expiratory events: on coughing and sneezing. J. Fluid Mech (2014), vol 745, pp 537-563. https://doi.org/10.1017/jfm.2014.88
26 Zayas, G., Chiang, M.C., Wong, E. et al. Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management. BMC Pulm Med 12, 11 (2012). https://doi.org/10.1186/1471-2466-12-11
27 Tang, J. W., Nicolle, A. D., Klettner, et al (2013). Airflow dynamics of human jets: sneezing and breathing – potential sources of infectious aerosols. PloS one, 8(4), e59970. https://doi.org/10.1371/journal.pone
28 Tongke Zhao, C Nguyen, Che-Hsuan Lin, H R. Middlekauff, K Peters, R Moheimani, Qiuju Guo & Yifang Zhu (2017). Characteristics of secondhand electronic cigarette aerosols from active human use, Aerosol Science and Technology, 51:12, 1368-1376, https://doi.org/10.1080/02786826.2017.1355548
29 D Martuzevicius, T Prasauskas, A Setyan, G O’Connell, X Cahours, R Julien, S Colard, Characterization of the Spatial and Temporal Dispersion Differences Between Exhaled E- Cigarette Mist and Cigarette Smoke, Nicotine & Tobacco Research, 2018, 1–7 https://doi.org/10.1093/ntr/nty121
30 Gupta JK, Lin CH, Chen Q (2010). Characterizing exhaled airflow from breathing and talking. Indoor Air 2010:20: 31–39. https://doi.org/10.1111/j.1600-0668.2009.00623.x
31 Van Doremalen N. Et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. The New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMc2004973?query=TOC